Renasight Genetic Testing

Renasight is a genetic test that helps individuals and families understand whether their kidney disease may have a genetic cause. Using a simple blood or saliva sample, Renasight analyzes 397 genes linked to kidney disease, including those associated with polycystic kidney disease (PKD), to help identify a genetic cause and clarify the chance of passing kidney disease on to future generations.

These insights can provide clarity for families affected by PKD by shedding light on who in the family may be at risk, enabling accurate counseling about reproductive risks, and allowing for more meaningful conversations with healthcare providers. Renasight can help provide a more precise diagnosis by determining if an individual or family is affected by the more common autosomal dominant form (ADPKD) or the more rare autosomal recessive form (ARPKD), which is usually more severe and is often diagnosed in infancy or even before birth. For those affected by ADPKD, Renasight may be able to confirm the precise genetic cause, which allows family members to be tested, and makes possible a wider array of family planning options for couples concerned about passing the condition on to their children. 

Genetic testing with Renasight can also identify carrier status for autosomal recessive PKD (ARPKD). ARPKD affects individuals who have 2 faulty copies of the gene responsible (PKHD1), usually inherited from parents who are both carriers. While carriers do not develop the disease themselves, this information is important because it can have implications for future generations and family planning decisions.

For individuals living with PKD or those with a family history of kidney disease, Renasight can be an important step in planning for the future. Genetic information may help empower individuals with knowledge as they explore their options and make informed decisions for themselves and their families.

To learn more about Renasight, download the patient brochure.

How to get started:

• Request a test kit

  • Click here to request a Renasight kit to be delivered to your home within 5-7 business days.

• Your provider submits an order.

  • Renasight requires a physician’s signature on the order form. Discuss with your physician if the test is right for you. You or your physician can call +1.650.425.4005 with any questions.

• Provide a saliva sample

  • The saliva sample is an easy cheek swab. Included in the kit are detailed collection instructions and a prepaid envelope to return the sample. If a blood sample is preferred, call +1.650.425.4005 and a complimentary at home mobile phlebotomy service can be scheduled at your convenience.

• Review your results with your provider.

  • Your Renasight results will be available in about 3 weeks to go over with your provider. Renasight offers a complimentary information session with a board-certified genetic counselor to answer any questions about your results.